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Scientific Vita

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PD Dr.

Thomas Wirth

Project: C05

Academic Education and Scientific Degrees

2015

Venia legendi in Experimental Gastroenterology

Since 2010

Research group leader, Department of Gastroenterology, Hepatology and Endocrinology (Chair: Prof. M. P. Manns), Hannover Medical School, Germany

2006-2009

Postdoctoral Research Scholar, Dept. of Microbiology, University of Iowa, Iowa City, USA (Prof. J. Harty)

2005-2006

Postdoctoral fellow, Hannover Medical School, Germany

2005

M.D. Thesis ("A telomerase-dependent conditionally replicating adenovirus for selective treatment of cancer", supervised by Prof. S. Kubicka, summa cum laude)

1999-2004

Study of Medicine, Hannover Medical School, Germany

1997-1999

Study of Medicine, University of Greifswald, Germany

Professional Career

Since 2017

Senior Physician, Department of Gastroenterology, Hepatology and Endocrinology, Chair: Prof. Manns, Medical School Hannover, Hannover, Germany

2015

Board Certification Internal Medicine and Gastroenterology

Since 2005

Assistant Doctor, Department of Gastroenterology, Hepatology, and Endocrinology (Chair: Prof. M. P. Manns), Hannover Medical School, Germany

2005

Medical Degree, Hannover Medical School, Germany

Address: Department of Gastroenterology, Hepatology, and Endocrinology
Hannover Medical School
Carl-Neuberg-Strasse 1
30625 Hannover
Phone: +49/511/532 9401
eMail: wirth.thomas@mh-hannover.de

Awards and Appointments

2010

GEROK fellowship (6 months)

2006-2009

Deutsche Forschungsgemeinschaft (DFG) Fellowship, University of Iowa, Iowa City, USA (Prof. J. Harty)

2005

Hochschulinterne Leistungsförderung (HiLF) Fellowship, Hannover Medical School, Germany

Publications

Ostroumov D, Duong S, Wingerath J, Woller N, Manns MP, Timrott K, Kleine M, Ramackers W, Roessler S, Nahnsen S, Czemmel S, Dittrich-Breiholz O, Eggert T, Kühnel F, Wirth TC. Transcriptome profiling identifies TIGIT as a marker of T cell exhaustion in liver cancer. Hepatology 2020. doi: 10.1002/hep.31466.

Owusu Sekyere S, Schlevogt B, Mettke F, Kabbani M, Deterding K, Wirth TC, Vogel A, Manns MP, Falk CS, Cornberg M, Wedemeyer H. HCC Immune Surveillance and Antiviral Therapy of Hepatitis C Virus Infection. Liver Cancer 2019;8:41-65.

Niemann J, Woller N, Brooks J, Fleischmann-Mundt B, Martin NT, Kloos A, Knocke S, Ernst AM, Manns MP, Kubicka S, Wirth TC, Gerardy-Schahn R, Kühnel F. Molecular retargeting of antibodies converts immune defense against oncolytic viruses into cancer immunotherapy. Nat Commun 2019;10:3236.

Wirth TC, Kühnel F. Neoantigen Targeting-Dawn of a New Era in Cancer Immunotherapy? Front Immunol 2017;8:1848.

Wingerath J, Ostroumov D, Woller N, Manns MP, Pinschewer DD, Orlinger K, Berka U, Kühnel F, Wirth TC. Recombinant LCMV Vectors Induce Protective Immunity following Homologous and Heterologous Vaccinations. Mol Ther 2017;25:2533-2545.

Nimanong S, Ostroumov D, Wingerath J, Knocke S, Woller N, Gürlevik E, Falk CS, Manns MP, Kühnel F, Wirth TC. CD40 Signaling Drives Potent Cellular Immune Responses in Heterologous Cancer Vaccinations. Cancer Res 2017;77:1918-1926.

Wirth TC, Manns MP. The impact of the revolution in hepatitis C treatment on hepatocellular carcinoma. Ann Oncol 2016;27:1467-74.

Brinkhoff B, Ostroumov D, Heemcke J, Woller N, Gürlevik E, Manns MP, Longerich T, Zender L, Harty JT, Kubicka S, Kühnel F, Wirth TC. Eur J Immunol 2013;44:1213-1224.

Woller N, Knocke S, Mundt B, Gürlevik E, Strüver N, Kloos A, Boozari B, Schache P, Manns MP, Malek NP, Sparwasser T, Zender L, Wirth TC, Kubicka S, Kühnel F. Virus-induced tumor inflammation facilitates effective DC cancer immunotherapy in a Treg-dependent manner in mice. J Clin Invest 2011;121:2570-2582.

Wirth TC, Xue HH, Rai D, Sabel JT, Bair T, Harty JT, Badovinac VP. Repetitive antigen stimulation induces stepwise transcriptome diversification but preserves a core signature of memory CD8(+) T cell differentiation. Immunity 2010;33:128-140.

Publications