Latest Publications

Rappez L, Stadler M. Heikenwalder M*, Aelxandrov T* (2021). SpaceM reveals metabolic states of single cells. Nat Methods, in press. * Co-last, co-corresponding author.

Deczkowska A, David E, Ramadori P, Pfister D, Safran M, Li B, Giladi A, Jaitin DA, Barboy O, Cohen M, Yofe I, Gur C, Shlomi-Loubaton S, Henri S, Suhail Y, Qiu M, Kam S, Hermon H, Lahat E, Ben-Yakov G, Cohen-Ezra O, Davidov Y, Likhter M, Goitein D, Roth S, Weber A, Malissen B, Weiner A*, Ben-Ari Z*, Heikenwalder M*, Elinav E*, Amit I* (2021). XCR1+ type 1 conventional dendritic cells drive liver pathology in Non-Alcoholic Steatohepatitis. Nat Med, in press. * Co-last, co-corresponding author.

Pfister D, Gonzalo Núñez N, Pinyol R, Govaere O, Pinter M, Szydlowska M, Gupta R, Qiu M, Deczkowska A, Weiner A, Müller F, Sinha A, Friebel E, Engleitner T, Lenggenhager D, Heide D, Stirm K, Kosla J, Youssuf S, Dudek M, Kotsiliti E, Ramadori P, Yahoo N, Leone V, Inverso D, Singh I, Castet F, Montironi C, Haber PK, Tiniakos D, Bedossa P, Cockell S, Younes R, Vacca M, Marra F, Schattenberg JM, Allison M, Bugianesi E, Ratziu V, Pressiani T, D'Alessio A, Personeni N, Rimassa L, Daly AK, Scheiner B, Pomej K, Kirstein MM, Vogel A, Peck-Radosavljevic M, Hucke F, Finkelmeier F, Waidmann O, Trojan J, Schulze K, Wege H, Koch S, Weinmann A, Bueter M, Rössler F, Müllhaupt B, Siebenhüner A, De Dosso S, Jugold M, Luedde T, Schietinger A, Schirmacher P, Augustin HG, Billeter A, Müller-Stich B, Wolter K, Zender L, Mei HE, Schulz AR, Ringelhan M, Malek N, Spahn S, Bitzer M, Lujambio A, Rahbari N, Dufour JF, Marron TU, Kaseb A, Kudo M, Huang YH, Teijeiro A, Djouder N, Weber A, Marche PN, Pinato DJ, Decaens T, Macek Jilkova Z, Rad R, Mertens JC, Unger K, Meissner F, Roth S, Claassen M, Anstee QM, Amit I, Becher B, Knolle P, Llovet JM*, Heikenwalder M* (2021) NASH limits anti-tumor surveillance in immunotherapy-treated hepatocellular carcinoma. Nature. doi: 10.1038/s41586-021-03362-0. *equal contribution.

Gengenbacher H, Singhal M, Mogler C, Hai L, Milde L, Abdul Pari AA, Besemfelder E, Fricke C, Baumann D, Gehrs S, Utikal J, Felcht M, Hu J, Schlesner M, Offringa R, Chintharlapalli SR, Augustin HG (2021) Timed Ang2-targeted therapy identifies the Angiopoietin-Tie pathway as key regulator of fatal lymphogenous metastasis. Cancer Discov, 11:424-445.

Winkler M, Staniczek T, Kürschner SW, Schmid CD, Schönhaber H, Cordero J, Kessler L, Mathes A, Sticht C, Neßling M, Uvarovskii A, Anders S, Zhang XJ, von Figura G, Hartmann D, Mogler C, Dobreva G, Schledzewski K, Géraud C, Koch PS, Goerdt S (2021) Endothelial GATA4 controls liver fibrosis and regeneration by preventing a pathogenic switch in angiocrine signaling. J Hepatol 74:380-393.

Roessler S, Edeline J, Schirmacher P*, Coulouarn C* (2021) Integrative genomics highlights opportunities for innovative therapies targeting the tumor microenvironment in gallbladder cancer. J Hepatol. doi: 10.1016/j.jhep.2020.12.024. *equal contribution.

Goeppert B, Stichel D, Toth R, Fritzsche S, Loeffler MA, Schlitter AM, Neumann O, Assenov Y, Vogel MN, Mehrabi A, Hoffmann K, Köhler B, Springfeld C, Weichenhan D, Plass C, Esposito I, Schirmacher P, von Deimling A, Roessler S (2021) Integrative analysis reveals early and distinct genetic and epigenetic changes in intraductal papillary and tubulopapillary cholangiocarcinogenesis. Gut. doi: 10.1136/gutjnl-2020-322983.

Kendre G, Marhenke S, Lorz G, Kühnel F, Woller N, Reineke-Plaaß T, Poth T, Becker D, Marquardt JU, Wirtz RM, Bonin M, Saborowski M, Vogel A*, Saborowski A* (2021). The co-mutational spectrum determines the therapeutic response in murine FGFR2 fusion - driven cholangiocarcinoma. Hepatology (accepted for publication). *equal contribution.

Filali-Mouncef Y*, Hunter C*, Roccio F*, Zagkou S*, Dupont N, Primard C, Proikas-Cezanne T, Reggiori F (2021) The ménage à trois of autophagy, lipid droplets and liver disease. Autophagy. doi: 10.1080/15548627.2021.1895658. *equal contribution.

Buitrago-Molina LE, Marhenke S, Becker D, Geffers R, Itzel T, Teufel A, Jaeschke H, Lechel A, Unger K, Markovic J, Sharma AD, Marquardt JU, Saborowski M, Saborowski A*, Vogel A* (2021). p53-independent induction of p21 fails to control regeneration and hepatocarcinogenesis in a murine liver injury model. Cell Mol Gastroenterol Hepatol S2352-345X(21)00012-6. *equal contribution.

Pellegrino R, Thavamani A, Calvisi DF, Budczies J, Neumann A, Geffers R, Kroemer J, Greule D, Schirmacher P, Nordheim A, Longerich T (2021) Serum Response Factor (SRF) drives the transcriptional upregulation of the MDM4 oncogene in HCC. Cancers (Basel) 13:199.

Dudek M, Pfister D, Donakonda S, Filpe P, Schneider A, Laschinger M, Hartmann D, Hüser N, Meiser P, Bayerl F, Inverso D, Wigger J, Sebode M, Öllinger R, Rad R, Roth S, Hegenbarth S, Anton M, Guillot A, Bowman A, Heide D, Müller M, Garcia Caceres C, Gruber T, Seifert G, Kabat A, Malm JP, Effenberger R, Billeter A, Müller-Stich B, Pearce EJ, Koch-Nolte F, Käser R, Tilg H, Thimme R, Böttler T, Tacke F, Dufour JF, Haller D, Murray P, Heeren R, Zehn D, Böttcher J, Heikenwalder M, Knolle P (2021) CXCR6 PD-1hiCD8 T cells cause liver immune pathology after metabolic activation in non-alcoholic steatohepatitis. Nature. doi: 10.1038/s41586-021-03233-8.

Mohs A, Otto T, Schneider KM, Peltzer M, Boekschoten M, Holland CH, Hudert CA, Kalveram L, Wiegand S, Saez-Rodriguez J, Longerich T, Hengstler JG, Trautwein C (2021) Hepatocyte-specific NRF2 activation controls fibrogenesis and carcinogenesis in steatohepatitis. J Hepatol 74:638-648.